The Gathering Place provides Adult Day services to promote empowerment, independence and quality of life for elders, adults with disabilities and their caregivers. We are dedicated to fostering collaborative community partnerships.

March 29, 2018

People with dementia due to Alzheimer’s disease are known to have disrupted sleep. New NIH-funded research, published online Jan. 29, 2018, in JAMA Neurology, links a disrupted sleep-wake cycle to an earlier, preclinical disease phase, in which people have evidence of the disease but no symptoms. The study, by researchers at the Knight Alzheimer's Disease Research Center at Washington University in St. Louis, Missouri, suggests that a fragmented sleep-wake cycle might be explored as a biomarker for preclinical Alzheimer’s.

For the study, 189 people (average age, 66 years) wore watch-like sensors for 7 to 14 days to collect data about their rest and activity levels. These participants also kept a sleep diary. In addition, they had positron emission tomography (PET) brain scans, cerebrospinal fluid analysis, or both to look for any biological signs of Alzheimer’s, including abnormal levels of the proteins amyloid and tau.

The researchers found that cognitively normal participants who had biological changes related to Alzheimer’s were more likely than those without these changes to have fragmented sleep-wake cycles, with higher-than-normal periods of rest during the day and more periods of activity at night.

Of the participants, 139 showed no evidence of Alzheimer’s, but 50 had abnormal amyloid plaques seen on PET scans or other signs of the disease. These 50 participants had more disruption in their circadian rest-activity (sleep-wake) cycles than those without evidence of Alzheimer’s. There were no significant differences between people with and without the ApoE4 genetic risk factor.

Increasing age also was associated with circadian dysfunction, particularly in men, the researchers found. However, after adjusting for age and gender, they concluded that aging and preclinical Alzheimer’s disease pathology have separate negative effects on circadian rhythm.

The question of whether circadian dysfunction contributes to Alzheimer’s disease pathology or vice versa is still being explored. Previous studies have shown a link between poor sleep quality and beta-amyloid levels in the brain, and findings in this study also suggest circadian dysfunction could contribute to early Alzheimer’s changes in the brain. Given that Alzheimer’s disease starts years before symptoms appear, these differences in the sleep-wake cycle could merit further study as an early indicator of disease.

Reference: Musiek ES, et al. Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease. JAMA Neurology. 2018 Jan 29. doi:10.1001/jamaneurol.2017.4719. [Epub ahead of print]

Older Bodies Handle Drugs Differently

As the body ages, its ability to break down substances can decrease. Because older people may not be able to metabolize drugs as well as they once did, they might need smaller doses of medicine per pound of body weight than young or middle-aged adults do.

Also, older adults frequently take more than one medication at a time. Medicines can interact with each other in unexpected ways, so anyone taking several medications at the same time should be extra careful.

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Fall Open House & Raffle for Art by Tim Wood

Join us for wine and refreshments November 6th, 2015 from 4 pm – 8 pm at 30 Terrace Street in Brattleboro VT. 

We'll be holding a raffle for art by Tim Wood as part of the event. Tickets can be purchased on our website or at 30 Terrace St., Brattleboro Drawing will be held on December 18, 2015. Winners will be called and announced on our Website & Facebook page!

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The Gathering Place provides Adult Day and other services to promote empowerment, independence and quality of life for elders, adults with disabilities and their caregivers. We are dedicated to fostering collaborative community partnerships.



Organizational Affiliations:

The Gathering Place is licensed annually by the Vermont Department of Aging and Disabilities (DAIL) and complies with Vermont Standards for Adult Day. The Gathering Place is contracted with Veterans Administration to serve those who have served our country and we are a United Way of Windham County (UWWC) partner agency. Additionally, we maintain memberships with:


NADSA - National Adult Day Services Association VAADS - Vermont Association of Adult Day Services
Brattleboro Area Chamber of CommerceCOVE – Community of Vermont Elders
BAPC – Brattleboro Area Prevention CoalitionNational Association for Home Care and Hospice (NAHC)
Private Duty Home Care Association (PDHCA)Home Care Technology Association (HCTAA)
Hospital Home Care Association (HHCA)Home Care Corporate Provider Alliance (HCCPA)


NAIPC supports The Gathering Place    United Way Supports The Gathering Place

The Gathering Place, Brattleboro Vermont

The Gathering Place is a not-for-profit 501©(3)organization that has proudly served the elders and adults with disabilities residents of Windham County since 1989.  Our organization is a vital member of the community in which we live and the surrounding towns in our service area - Acton, Athens, Bartonsville, Bellows Falls, Brattleboro, Brookline, Cambridgeport, Dover, Dummerston, Grafton, Guilford, Halifax, Jacksonville, Jamaica, Londonderry, Marlboro, Newfane, Putney, Rockingham, Saxons River, Somerset, Stratton, Townshend, Vernon, Wardsboro, Westminster, Whitingham, Wilmington and Windham.  Seniors and adult disabled individuals of all ages, races, religions and socioeconomic status enjoy the benefits of the Center and its services every day.

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